Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery Basic Principles and Biological Examples by Kishor M. Wasan

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Number of Pages205
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ISBN 100471739529
ISBN 109780471739524

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KISHOR M. WASAN, PhD, is a Professor and Distinguished University Scholar at The University of British Columbia Faculty of Pharmaceutical is the Chairman of the AAPS Focus Group in Parenteral Lipid-Based Drug Delivery Systems.

His research has earned him over $10 million in grants and funding, and he has written over peer-reviewed publications and abstracts. Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples [Wasan, Kishor M.] on *FREE* shipping on qualifying offers.

Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples. Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples Kishor M.

Wasan (Editor) ISBN: January Pages. Get this from a library. Role of lipid excipients in modifying oral and parenteral drug delivery: basic principles and biological examples. [Kishor M Wasan;] -- Lipid-based drug delivery systems is an emerging field that uses lipids to make drugs more soluble in water and better able to function in the body.

This book assembles a group of experienced authors. Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery January Publisher: Wiley-Interscience,Hardcover, pp. ISBN About the Author KISHOR M.

WASAN, PhD, is a Professor and Distinguished University Scholar at The University of British Columbia Faculty of Pharmaceutical is the Chairman of the AAPS Focus Group in Parenteral Lipid-Based Drug Delivery Systems. His research has earned him over $10 million in grants and funding, and he has written over peer-reviewed publications and abstracts.

Free Online Library: Role of lipid excipients in modifying oral and parenteral drug delivery; basic principles and biological examples.(Brief Article, Book Review) by "SciTech Book News"; Publishing industry Library and information science Science and technology, general Books Book.

Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery - ISBN: - (ebook) - von Kishor M. Wasan, Verlag: Wiley. Wasan, K: Role of Lipid Excipients in Modifying Oral and Par: Basic Principles and Biological Examples (Inglés) Tapa dura – Ilustrado, 27 octubre de Kishor M.

Wasan (Redactor) Ver Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery book He is the Chairman of the AAPS Focus Group in Parenteral Lipid-Based Drug Delivery Systems. His research has earned him over $10 million in grants and Format: Tapa dura.

Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples. Kishor M. Wasan ; Sterile Filtration: A Practical W.

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Wayne Rogers Role of lipids in oral drug delivery The therapeutic efficaciousness of a drug poorly soluble in water will be improved by increasing its gi solubilization with concomitant modification of pharmacokinetic.

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In download role of lipid excipients in modifying oral and parenteral drug delivery basic principles and biological, it is read with a mm book. Canada Research Chair in Drug Delivery, Faculty of Pharmacy, University of Montreal, Canada University of Montreal, Canada.

Search for more papers by this author. Book Editor(s): Kishor M. Wasan. University of British Columbia, Vancouver, British Columbia, Canada. Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery. In book: Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples (pp - 87).

Oral Drug Delivery. Alternative Drug Delivery Routes. Dermal Drug Delivery. Technical Support. Properties of Cannabinoids. The Benefits of Lipid Based Excipients in: This brochure provides an overview of the formulation opportunities with Gattefossé excipients in developing medicinal cannabinoids for oral, topical, transdermal, and.

Parenteral drug delivery plays a very vital role in pharmacotherapy of various acute and critical illnesses. Injectables have been preferred formulations over oral and topicals especially in case where rapid effects of drugs are required or prolongation of drug release is desired.

Lipid drug delivery systems. Lipid-based DDS are an accepted, proven, commercially viable strategy to formulate pharmaceuticals for topical, oral, pulmonary or parenteral delivery. Lipid formulations can be tailored to meet a wide range of product requirements.

One of the earliest lipid DDS- liposomes have been used to improve drug solubility. Author(s): Wasan,Kishor M Title(s): Role of lipid excipients in modifying oral and parenteral drug delivery: basic principles and biological examples/ edited by Kishor M.

Wasan. Country of Publication: United States Publisher: Hoboken, N.J.: Wiley-Interscience, c Lipid excipients delivery the drug by creating an insoluble matrix structure from which diffusion is the principal drug release mechanism.

It not only forms a water-insoluble matrix, but provides pH-independent release, non-digestible, highly resistant to physiological conditions, and does not result in alcohol-related dose dumping.

In formulation of SEEDS, other than previously mentioned excipients, other excipients such as viscosity enhancers, excipients for modified release of drug and antioxidants are commonly used. Viscosity enhancers, such as tragacanth, cetyl alcohol, stearic acid, or beeswax can be added to the formulation in order to modify consistency and enhance.

This review provides a brief on lipid-based drug delivery nanocarrier and the mechanisms by which lipids and lipidic excipients improve the oral absorption of drugs with poor aqueous solubility and also provide a viewpoint on the promising applications of lipidic nanoparticulate systems.

Müller RH. Solid lipid nanoparticles for parenteral. For oral drug candidates with very a limited fraction absorbed it is advisable to test multiple formulation approaches based on nanoparticles, solid dispersions or lipid-based drug-delivery systems.

Solubility of active pharmaceutical ingredients can be improved by employing metastable states that form supersaturating drug-delivery systems in. In the recent era, considerable focus is placed on novel drug delivery systems (NDDSs) as they accomplish two basic requirements.3 Drug delivery occurs at a predefined rate based on body needs.

The active pharmaceutical ingredient is delivered at the target site, thereby improving its therapeutic effectiveness.4 However, lipid-based drug delivery systems promise to improve drug delivery.

A review of commercially available oral and injectable solution formulations reveals that the solubilizing excipients include water-soluble organic solvents (polyethylene glycolpolyethylene glycolethanol, propylene glycol, glycerin, N-methylpyrrolidone, dimethylacetamide, and dimethylsulfoxide), non-ionic surfactants (Cremophor EL, Cremophor RH 40, Cremophor RH 60, d-α.

Wissing SA, Kayser O, Muller RH () Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56(9)– PubMed CrossRef Google Scholar Wong HL, Bendayan R, Rauth AM et al (a) A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid.

These benefits can be realized for patients with a wide range of disease indications. In addition, lipid-based drug-delivery systems (LBDDSs) can be used to formulate drugs in the most common dosage forms, including topical, oral, pulmonary, or parenteral administration.

Several Approvals and Many Lipid-Based Drugs in Development. In oral drug delivery, the most commonly used counterions over the past three decades include hydrochloride, maleate, mesylate, and phosphate for basic drugs, and calcium, magnesium, potassium, and sodium for acidic drugs.

2 More recently, there has been a growing interest in lipophilic salt forms that exhibit lower melting points than. In this exclusive Drug Development & Delivery magazine annual report, excipient manufacturers describe how their excipient offerings are improving drug release, solubility, taste, physical characteristics, viscosity, and more, for a range of molecules.

ABITEC: Functional Lipid Excipients Combine for Enhanced Solubility. The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept.

Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs.

Investigation of Excipient Compatibility and Associated Degradations for the Formulation Development of a Small Molecule Pharmaceutical Compound; Rapid Detection of Counterfeit Drugs of Ethambutol Hydrochloride and Cefuroxime Axetil using Handheld Raman, Near Infrared and Portable FTIR Technologies; Future of Transdermal Drug Delivery Systems.

Lipid-Based Excipients for Oral Drug Delivery With Lowell Gibson The goal of an oral lipid based formulation is to improve the bioavailability of a poorly water soluble drug to an extent greater than that achievable with a conventional oral solid dosage form. drug into a dosage form or drug delivery system that translates drug discovery and pharmacological research into clinical practice.

Indeed the drug delivery system employed plays a vital role in controlling the pharmacological effect of the drug as it can influence the pharmacokinetic profile of the drug, the rate of drug release, the site and. Handbook of Pharmaceutical Excipients, 5th ed.

(CD-ROM included). Role of lipid excipients in modifying oral and parenteral drug delivery; basic principles and biological examples. Ruger Chemical Co., Inc. Ruger Chemical Co., Inc. It is approved for oral and parenteral administration in humans by the EU, US, and Chinese regulatory authorities.

In this short communication, we will review treatment strategies and the potential role of cyclodextrins in combating the illness as an excipient, adjuvant and potentially an API. Cyclodextrin drug delivery systems can effectively overcome formulation challenges of antiviral drugs by offering improved solubility and bioavailability.

HPβCD is cited in the FDA’s list of Inactive Pharmaceutical Ingredients, and is approved for use in oral and parenteral formulations due to its high aqueous solubility and excellent safety. Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients.

These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size.

Role of Lipid Excipients in Modifying Oral And Parenteral Drug Delivery: Bas $ $ A new, unread, unused book in perfect condition with no missing or damaged pages. See the seller’s listing for full details.

Lipid Rafts Properties and Role in Signaling by Nils Thomas (Paperback, )Seller Rating: % positive. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications.

Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.3/5(1).

FROST & SULLIVAN’S latest analysis, ‘Global Pharmaceutical Functional and Multifunctional Excipients Market, Forecast to ’, reveals that the development of innovative drug delivery technologies, a growing generic and biosimilar drug market and an ageing population are key factors increasing demand for functional and multifunctional excipients in the pharmaceutical industry.

Solid lipid nanoparticles (SLNs), or lipid nanoparticles (LNPs), are nanoparticles composed of are a novel pharmaceutical drug delivery system (and part of nanoparticle drug delivery), and a novel pharmaceutical formulation. LNPs as a drug delivery vehicle were first approved in for the siRNA drug, Onpattro.

LNPs came to wider prominence inas some candidate COVID. Lipid excipients are comprised of a large group of physically and chemically diverse glycerides, which may be used in simple (single oil solutions of the drug substance) or in more complex nanocarriers (SMEDDS/SNEDDS, drug dissolved in the mixture of glyceride, surfactant and or cosolvent), with considerable flexibility in formulation design.ROLE OF LIPID EXCIPIENTS IN MODIFYING ORAL AND PARENTERAL DRUG By Kishor M.

NEW. $ Free shipping. A First Course in Analytical Mechanics by Klaus Rossberg. $ Free shipping. Review & Research on Natural Excipients in Drug Delivery by Subas Chandra Dinda. $ Free shipping. ANALYTICAL EXPERIMENTAL PHYSICS, BY FERENCE, LEMON Seller Rating: % positive. In the present study, haloperidol (HP)-loaded solid lipid nanoparticles (SLNs) were prepared to enhance the uptake of HP to brain via intranasal (i.n.) delivery.

SLNs were prepared by a modified emulsification–diffusion technique and evaluated for particle size, zeta potential, drug entrapment efficiency, in vitro drug release, and stability. All parameters were found to be in an .

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